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Título: | Complete inhibition of extranodal dissemination of lymphoma by edelfosine-loaded lipid nanoparticles |
Autor: | Estella-Hermoso de Mendoza, A.; Campanero, Miguel A.; Villa-Pulgarín, J. A.; Iglesia-Vicente, Janis de la; Mollinedo, Faustino CSIC ORCID ; Blanco-Prieto, María J. | Fecha de publicación: | 2012 | Editor: | Future Medicine | Citación: | Nanomedicine 7(5): 679-690 (2012) | Resumen: | [Background]: Lipid nanoparticles (LNs) made of synthetic lipids Compritol® 888 ATO and Precirol® ATO 5 were developed with an average size of 110.4 ± 2.1 and 103.1 ± 2.9 nm, and an encapsulation efficiency above 85% for both type of lipids. These LNs decrease the hemolytic toxicity of the drug by 90%. [Materials & methods]: Pharmacokinetic and biodistribution profiles of the drug were studied after intravenous and oral administration of edelfosine-containing LNs. [Results]: This provided an increase in relative oral bioavailability of 1500% after a single oral administration of drug-loaded LNs, maintaining edelfosine plasma levels over 7 days in contrast to a single oral administration of edelfosine solution, which presented a relative oral bioavailability of 10%. Moreover, edelfosine-loaded LNs showed a high accumulation of the drug in lymph nodes and resulted in slower tumor growth than the free drug in a murine lymphoma xenograft model, as well as potent extranodal dissemination inhibition. Original submitted 5 April 2011; Revised submitted 5 July 201. © 2012 Future Medicine Ltd. | URI: | http://hdl.handle.net/10261/59951 | DOI: | 10.2217/nnm.11.134 | Identificadores: | issn: 1743-5889 e-issn: 1748-6963 |
Aparece en las colecciones: | (IBMCC) Artículos |
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