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Title

Biological activity of secondary metabolites from Bupleurum salicifolium (Umbelliferae)

AuthorsGonzález-Pérez, José Antonio ; Estévez Braun, Ana; Bazzocchi, Isabel L.; Moujir, Laila; Jiménez Díaz, Ignacio Antonio; Ravelo, Ángel G.; González, A. G.
KeywordsUmbelliferae
Bupleurum salicifolium
Biological activity
Polyacetylenes
Lignans
Issue DateJan-1995
PublisherSpringer
CitationExperientia 51(1): 35-39 (1995)
AbstractSecondary metabolites from Bupleurum salicifolium were tested against viruses, Gram-positive and Gram-negative bacteria, the yeast Candida albicans, the nematodes Globodera pallida and G. rostochiensis, the insect Spodoptera littoralis and the crustacean Artemia salina. These compounds were also tested against tumoral and non-tumoral cell lines. The polyacetylene 8S-heptadeca-2(Z)-9(Z)-diene-4,6-diyne-1,8-diol exhibited toxicity for A. salina and specific antibiotic activity against Gram-positive bacteria. Nine of the lignans and one coumarin showed toxicity for A. salina, and the lignans bursehernin and matairesinol inhibited the hatching of the two nematode species. These are the first lignans that have been reported as affecting phytoparasitic nematodes, and the first natural products known to have an effect on the hatching of G. pallida. Lignans may play a role in the defence mechanisms of potato plants, as allelopathic substances acting against cyst-forming nematodes.
URIhttp://hdl.handle.net/10261/59870
ISSN0014-4754
Appears in Collections:(IRNAS) Artículos
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