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Cloning and genomic characterization of sytdep, a new synaptotagmin XIV-related gene

AuthorsHerrero-Turrión, M. Javier; Fukuda, Mitsunori; Mollinedo, Faustino
Issue Date10-Feb-2006
CitationBiochemical and Biophysical Research Communications 340(2): 386-394 (2006)
AbstractWe have identified a new human gene coined sytdep (synaptotagmin XIV-derived protein) in human neutrophils. Sytdep encodes a 188-amino acid sequence with a 21.435 kDa deduced molecular mass, showing 75% identity to human synaptotagmin (syt) XIV. Human neutrophils express sytdep, but not syt XIV. Sytdep was upregulated during HL-60 neutrophil differentiation. Sytdep gene is located in human chromosome 4 and contains a unique exon, whereas syt XIV gene, located in chromosome 1, comprises 10 exons with 9 introns. Mouse genome did not contain sytdep. The N-terminal region of sytdep shows no homology with any known protein and, unlike synaptotagmin XIV isoforms, sytdep shows a unique C-terminal C2B domain. Polyclonal antibodies against the C2B domain of syt XIV recognized sytdep as a 27-kDa protein in human neutrophils. Genomic analyses suggest that human sytdep could derive from a retrotranslocation of a syt XIV transcript into chromosome 4. © 2005 Elsevier Inc. All rights reserved.
Publisher version (URL)http://doi.org/10.1016/j.bbrc.2005.11.184
Identifiersissn: 0006-291X
Appears in Collections:(IBMCC) Artículos
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