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Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription

AuthorsGuillamot, María; Manchado, Eusebio; Chiesa, Massimo; Gómez-López, Gonzalo; Pisano, David G.; Sacristán, María P. ; Malumbres, Marcos
Issue Date2011
PublisherNature Publishing Group
CitationScientific Reports 1: 189 (2011)
AbstractCdc14 is an essential phosphatase in yeast but its role in the mammalian cell cycle remains obscure. We report here that Cdc14b-knockout cells display unscheduled induction of multiple cell cycle regulators resulting in early entry into DNA replication and mitosis from quiescence. Cdc14b dephosphorylates Ser5 at the C-terminal domain (CTD) of RNA polymerase II, a major substrate of cyclin-dependent kinases. Lack of Cdc14b results in increased CTD-Ser5 phosphorylation, epigenetic modifications that mark active chromatin, and transcriptional induction of cell cycle regulators. These data suggest a function for mammalian Cdc14 phosphatases in the control of transcription during the cell cycle.
DescriptionThis work is licensed under a Creative Commons Attribution-NonCommercial.
Publisher version (URL)http://dx.doi.org/10.1038/srep00189
Identifiersdoi: 10.1038/srep00189
issn: 2045-2322
Appears in Collections:(IBMCC) Artículos
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