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Title

A comparative histochemical study of diphosphatenucleosidases and thiaminepyrophosphatase in the mammalian hypothalamus

AuthorsMartínez-Rodríguez, Ricardo; Martínez-Murillo, Ricardo ; Toledano Gasca, Adolfo ; Barca, M. A.
Issue Date1980
PublisherBlackwell Publishing
CitationJournal of Anatomy 130: 173- 182 (1980)
AbstractNDPase and TPPase activities were detected by histochemical techniques in the hypothalamus of rat, cat and man. Both enzymatic activities were exhibited by neurons and glial cells, the latter hydrolyzing NDP more actively than TPP. Enzyme hydrolysis of NDP and TPP was activated by imidazole and inhibited by noradrenaline, L-DOPA, L-cysteine and KF. The results could be explained by postulating a common enzyme (probably two iso-enzymes) for NDP and TPP hydrolysis. The location of NDPase and TPPase in synaptic sites suggests that these enzymes may be involved in neurotransmission.
URIhttp://hdl.handle.net/10261/59578
ISSN0021-8782
Appears in Collections:(IC) Artículos
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