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Title

A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton

AuthorsSauzeau, Vincent; Berenjeno, Inmaculada M.; Citterio, Carmen; Bustelo, Xosé R.
Issue Date2010
PublisherLandes Bioscience
CitationSmall GTPases 1(1): 69-74 (2010)
AbstractThe GTPase RhoA and the transcriptional factor c-Myc are closely intertwined in cancer cells. Although this cross-talk results in potent synergistic effects that favor the transformed phenotype of cancer cells, recent results from our laboratory indicate that c-Myc also participates in a negative feed-back loop that blocks specific RhoA signaling branches connected to the induction of stress fibers, focal adhesions and actomyosin contractility. Using microarray analysis, we have unveiled a RhoA/c- Myc-dependent gene signature in charge of this negative cross-talk. This signature is composed of upregulated and repressed transcripts encoding cytoskeletal modulators located downstream of both RhoA and Rock. Our results also indicate that this negative feed-back loop modifies the invasion and adhesion properties of RhoA-transformed cells, suggesting that it may be important to ensure fluid cytoskeletal dynamics of cancer cells. Preliminary data indicate that c-Myc may also use a different transcriptional program to interfere with the RhoA/ Rock-dependent cytoskeletal branch in non-transformed cells. © 2010 Landes Bioscience.
DescriptionEl pdf del artículo es el manuscrito de autor: PMC2896432
Publisher version (URL)http://dx.doi.org/10.4161/sgtp.1.1.12986
URIhttp://hdl.handle.net/10261/59468
DOI10.4161/sgtp.1.1.12986
Identifiersdoi: 10.4161/sgtp.1.1.12986
issn: 2154-1248
e-issn: 2154-1256
Appears in Collections:(IBMCC) Artículos
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