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dc.contributor.authorSauzeau, Vincent-
dc.contributor.authorBerenjeno, Inmaculada M.-
dc.contributor.authorCitterio, Carmen-
dc.contributor.authorBustelo, Xosé R.-
dc.identifierdoi: 10.4161/sgtp.1.1.12986-
dc.identifierissn: 2154-1248-
dc.identifiere-issn: 2154-1256-
dc.identifier.citationSmall GTPases 1(1): 69-74 (2010)-
dc.descriptionEl pdf del artículo es el manuscrito de autor: PMC2896432-
dc.description.abstractThe GTPase RhoA and the transcriptional factor c-Myc are closely intertwined in cancer cells. Although this cross-talk results in potent synergistic effects that favor the transformed phenotype of cancer cells, recent results from our laboratory indicate that c-Myc also participates in a negative feed-back loop that blocks specific RhoA signaling branches connected to the induction of stress fibers, focal adhesions and actomyosin contractility. Using microarray analysis, we have unveiled a RhoA/c- Myc-dependent gene signature in charge of this negative cross-talk. This signature is composed of upregulated and repressed transcripts encoding cytoskeletal modulators located downstream of both RhoA and Rock. Our results also indicate that this negative feed-back loop modifies the invasion and adhesion properties of RhoA-transformed cells, suggesting that it may be important to ensure fluid cytoskeletal dynamics of cancer cells. Preliminary data indicate that c-Myc may also use a different transcriptional program to interfere with the RhoA/ Rock-dependent cytoskeletal branch in non-transformed cells. © 2010 Landes Bioscience.-
dc.description.sponsorshipX.R.B. work is supported by grants from the NIH (5R01-CA73735-13), the Spanish Ministry of Science and Innovation (SAF2009-07172 and RD06/0020/0001), the Castilla y León Autonomous Government (GR97) and the 7th Framework European Union Program (FP7-HEALTH-2007-A-201862) .-
dc.publisherLandes Bioscience-
dc.titleA transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton-
dc.description.versionPeer Reviewed-
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