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Association between the proliferative rate of neoplastic B cells, their maturation stage, and underlying cytogenetic abnormalities in B-cell chronic lymphoproliferative disorders: Analysis of a series of 432 patients

AuthorsQuijano, Sandra; López, Antonio; Rasillo, Ana; Barrena, Susana; Sánchez, Maria Luz; Flores-Montero, Juan; Fernández, Carlos; Sayagués, José María ; Díaz-Mediavilla, J.; Almeida, Julia ; Orfao, Alberto
Issue Date2008
PublisherAmerican Society of Hematology
CitationBlood 111(10): 5130-5141 (2008)
AbstractLimited knowledge exists about the impact of specific genetic abnormalities on the proliferation of neoplastic B cells from chronic lymphoproliferative disorders (B- CLPDs). Here we analyze the impact of cytogenetic abnormalities on the proliferation of neoplastic B cells in 432 B-CLPD patients, grouped according to diagnosis and site of sampling, versus their normal counterparts. Overall, proliferation of neoplastic B cells highly varied among the different B-CLPD subtypes, the greatest numbers of proliferating cells being identified in diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). Compared with normal B cells, neoplastic B-CLPD cells showed significantly increased S + G2/M-phase values in mantle cell lymphoma (MCL), B-chronic lymphocytic leukemia (B-CLL), BL, and some DLBCL cases. Conversely, decreased proliferation was observed in follicular lymphoma, lymphoplasmacytic lymphoma/ Waldenstrom macroglobulinemia (LPL/ WM), and some DLBCL patients; hairy cell leukemia, splenic marginal zone, and MALT-lymphoma patients showed S + G 2/ M phase values similar to normal mature B lymphocytes from LN. Interestingly, in B-CLL and MCL significantly higher percentages of S + G 2/M cells were detected in BM versus PB and in LN versus BM and PB samples, respectively. In turn, presence of 14q32.3 gene rearrangements and DNA aneuploidy, was associated with a higher percentage of S + G2/M-phase cells among LPL/WM and B-CLL cases, respectively. © 2008 by The American Society of Hematology.
DescriptionTrabajo presentado al "13th Congress of the European Hematology Association" celebrado en Copenhague en Junio del 2008.-- et al.
Identifiersdoi: 10.1182/blood-2007-10-119289
issn: 0006-4971
e-issn: 1528-0020
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