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Lytic Activity of LysH5 Endolysin Secreted by Lactococcus lactis Using the Secretion Signal Sequence of Bacteriocin Lcn972

AuthorsRodríguez, Lorena CSIC ORCID; Gutiérrez, Dolores; Martínez Fernández, Beatriz CSIC ORCID ; Rodríguez González, Ana CSIC ORCID; García Suárez, María Pilar CSIC ORCID
Issue Date17-Feb-2012
PublisherAmerican Society for Microbiology
CitationApplied and Environmental Microbiology 78(9): 3469-3472 (2012)
AbstractBacteriophage endolysins have an interesting potential as antimicrobials. The endolysin LysH5, encoded by Staphylococcus aureus phage vB_SauS-phi-IPLA88, was expressed and secreted in Lactococcus lactis using the signal peptide of bacteriocin lactococcin 972 and lactococcal constitutive and inducible promoters. Up to 80 U/mg of extracellular active endolysin was detected in culture supernatants, but most of the protein (up to 323 U/mg) remained in the cell extracts.
Publisher version (URL)http://dx.doi.org/10.1128/​AEM.00018-12
Appears in Collections:(IPLA) Artículos
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