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A modular approach to trim cellular targets in anticancer drug discovery

AuthorsRíos-Luci, Carla; Díaz-Rodríguez, Elena ; Pandiella, Atanasio
Issue Date2011
CitationBioorganic and Medicinal Chemistry Letters 21(22): 6641-6645 (2011)
AbstractA Phenotypic Drug Discovery strategy was applied to study a set of pyrimidine analogs prepared by means of intramolecular oxidation-reduction reactions of N-substituted-N-(2,6-disubstituted-5-nitro-4-pyrimidinyl) aminoacetic acid methyl esters in basic media. The combined and rational use of specific assays allowed in short time reducing from all possible cellular targets to those involved in metaphase to anaphase transition. © 2011 Elsevier Ltd. All rights reserved.
Identifiersdoi: 10.1016/j.bmcl.2011.09.069
issn: 0960-894X
Appears in Collections:(IBMCC) Artículos
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