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dc.contributor.author | Madrid, Rodolfo | - |
dc.contributor.author | Peña, Elvira de la | - |
dc.contributor.author | Donovan-Rodriguez, Tansy | - |
dc.contributor.author | Belmonte, Carlos | - |
dc.contributor.author | Viana, Félix | - |
dc.date.accessioned | 2012-10-31T08:57:55Z | - |
dc.date.available | 2012-10-31T08:57:55Z | - |
dc.date.issued | 2009 | - |
dc.identifier | doi: 10.1523/JNEUROSCI.4778-08.2009 | - |
dc.identifier | issn: 0270-6474 | - |
dc.identifier | e-issn: 1529-2401 | - |
dc.identifier.citation | Journal of Neuroscience 29(10): 3120- 3131 (2009) | - |
dc.identifier.uri | http://hdl.handle.net/10261/59271 | - |
dc.description.abstract | Molecular determinants of threshold differences among cold thermoreceptors are unknown. Here we show that such differences correlate with the relative expression of IKD, a current dependent on Shaker-like Kv1 channels that acts as an excitability brake, and ITRPM8, a cold-activated excitatory current. Neurons responding to small temperature changes have high functional expression of TRPM8 (transient receptor potential cation channel, subfamily M, member 8) and low expression of IKD. In contrast, neurons activated by lower temperatures have a lower expression of TRPM8 and a prominent IKD. Otherwise, both subpopulations have nearly identical membrane and firing properties, suggesting that they belong to the same neuronal pool. Blockade of IKD shins the threshold of cold-sensitive neurons to higher temperatures and augments cold-evoked nocifensive responses in mice. Similar behavioral effects of IKD blockade were observed in TRPA1-/- mice. Moreover, only a small percentage of trigeminal cold-sensitive neurons were activated by TRPA1 agonists, suggesting that TRPA1 does not play a major role in the detection of low temperatures by uninjured somatic cold-specific thermosensory neurons under physiological conditions. Collectively, these findings suggest that innocuous cooling sensations and cold discomfort are signaled by specific low- and high-threshold cold thermoreceptor neurons, differing primarily in their relative expression of two ion channels having antagonistic effects on neuronal excitability. Thus, although TRPM8 appears to function as a critical cold sensor in the majority of peripheral sensory neurons, the expression of Kv1 channels in the same terminals seem to play an important role in the peripheral gating of cold-evoked discomfort and pain. Copyright © 2009 Society for Neuroscience. | - |
dc.description.sponsorship | This work was supported by funds from the Spanish Ministry of Education and Science: Projects BFU2007-61855 to F.V., and BFU2005-08741 and CONSOLIDER-INGENIO 2010 CSD2007-00023 to C.B., and the Spanish Fundación Marcelino Botín | - |
dc.language.iso | eng | - |
dc.publisher | Society for Neuroscience | - |
dc.rights | openAccess | - |
dc.title | Variable threshold of trigeminal cold-thermosensitive neurons is determined by a balance between TRPM8 and Kv1 potassium channels | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1523/JNEUROSCI.4778-08.2009 | - |
dc.date.updated | 2012-10-31T08:57:55Z | - |
dc.description.version | Peer Reviewed | - |
dc.identifier.pmid | 19279249 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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