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Acute lymphoblastic leukemia and developmental biology: A crucial interrelationship

AuthorsCampos-Sánchez, Elena CSIC ORCID ; Toboso-Navasa, Amparo; Romero-Camarero, Isabel CSIC ORCID; Barajas-Diego, Marcos CSIC; Sánchez García, Isidro CSIC ORCID ; Cobaleda, César CSIC ORCID
Issue Date2011
PublisherLandes Bioscience
CitationCell Cycle 10(20): 3473-3486 (2011)
AbstractThe latest scientific findings in the field of cancer research are redefining our understanding of the molecular and cellular basis of the disease, moving the emphasis toward the study of the mechanisms underlying the alteration of the normal processes of cellular differentiation. The concepts best exemplifying this new vision are those of cancer stem cells and tumoral reprogramming. The study of the biology of acute lymphoblastic leukemias (ALLs) has provided seminal experimental evidences supporting these new points of view. Furthermore, in the case of B-cells, it has been shown that all the stages of their normal development show a tremendous degree of plasticity, allowing them to be reprogrammed to other cellular types, either normal or leukemic. Here we revise the most recent discoveries in the fields of B-cell developmental plasticity and B-ALL research, and discuss their interrelationships and their implications for our understanding of the biology of the disease. © 2011 Landes Bioscience.
DescriptionThis is an open access article.
Publisher version (URL)http://dx.doi.org/10.4161/cc.10.20.17779
Identifiersissn: 1538-4101
e-issn: 1551-4005
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