English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/58868
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Proteome-Wide Analysis of Functional Divergence in Bacteria: Exploring a Host of Ecological Adaptations

AuthorsCaffrey, Brian E.; Williams, Tom A.; Jiang, Xiaowei; Toft, Christina ; Hokamp, Karsten; Fares, Mario A.
KeywordsDetecting Posistive Selection
Amino-Acid Sites
Bartonella Bacilliformis
Escherichia-Coli
Genome Sequence
Molecular-Adaptation
Statistical Methods
Maximum Lekelihood
Gene Duplication
Cog Database
Issue DateApr-2012
PublisherPublic Library of Science
CitationPlos One 7/4: e35659 (2012)
AbstractBoth genetic and environmental factors influence the evolution of new functions, including gene duplication or changes in the ecological requirements of an organism. Novel functions emerge at the expense of ancestral ones and are generally accompanied by changes in the selective forces at constrained protein regions. We present software capable of analyzing whole proteomes, identifying putative amino acid replacements leading to functional change in each protein and performing statistical tests on all tabulated data. We apply this method to 750 complete bacterial proteomes to identify high-level patterns of functional divergence and link these patterns to ecological adaptations. Proteome-wide analyses of functional divergence in bacteria with different ecologies reveal a separation between proteins involved in information processing (Ribosome biogenesis etc.) and those which are dependent on the environment (energy metabolism, defense etc.). We show that the evolution of pathogenic and symbiotic bacteria is constrained by their association with the host, and also identify unusual events of functional divergence even in well-studied bacteria such as Escherichia coli. We present a description of the roles of phylogeny and ecology in functional divergence at the level of entire proteomes in bacteria.
Publisher version (URL)http:// dx.doi:10.1371/journal.pone.0035659
URIhttp://hdl.handle.net/10261/58868
E-ISSN1932-6203
Appears in Collections:(IBMCP) Artículos
Files in This Item:
File Description SizeFormat 
PlosOne_7_e35659.pdf524,88 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.