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Deletion of LCE3C and LCE3B is a susceptibility factor for psoriatic arthritis: A study in Spanish and Italian populations and meta-analysis

AuthorsDocampo, E.; Giardina, E.; Riveira-Muñoz, Eva; Cid, R. de; Escaramís, G.; Perricone, C.; Fernández-Sueiro, J. L.; Maymõ, J.; González-Gay, M. A.; Blanco, Francisco J. ; Hüffmeier, U.; Lisbona, M. P.; Martín, J.; Carracedo, A.; Reis, A.; Rabionet, R.; Novelli, G.; Estivill, X.
Issue Date2011
PublisherJohn Wiley & Sons
CitationArthritis and Rheumatism 63: 1860- 1865 (2011)
AbstractObjective The LCE3C-LCE3B-del variant is associated with psoriasis and rheumatoid arthritis. Its role in psoriatic arthritis (PsA) is unclear, however, as shown by 3 recent studies with contradictory results. In order to investigate whether LCE3C-LCE3B-del constitutes a risk factor for PsA susceptibility, we first tested this variant in patients with PsA from Spanish and Italian populations and then performed a meta-analysis including the previous case-control studies. Methods We genotyped LCE3C-LCE3B-del and its tag single-nucleotide polymorphism (SNP), rs4112788, in an original discovery cohort of 424 Italian patients with PsA and 450 unaffected control subjects. A Spanish replication cohort consisting of 225 patients with PsA and 469 control subjects was also genotyped. A meta-analysis considering 7,758 control subjects and 2,325 patients with PsA was also performed. Results We observed a significant association between PsA and the LCE3C-LCE3B-del tag SNP in the Italian and Spanish cohorts, with an overall corrected P value of 0.00019 and a corresponding odds ratio of 1.35 (95% confidence interval 1.14-1.59). Stratified analyses by subphenotype indicated a stronger association for patients with oligoarticular disease. Meta-analysis including data from all previous published studies confirmed an association of PsA with the LCE3C-LCE3B-del tag SNP. Conclusion LCE3C-LCE3B-del is a susceptibility factor for PsA, confirming the existence of a shared risk factor involving the epidermal skin barrier in autoimmune disorders. Copyright © 2011 by the American College of Rheumatology.
Identifiersdoi: 10.1002/art.30340
issn: 0004-3591
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