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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Saby, Emilie | - |
dc.contributor.author | Poulsen, J. B. | - |
dc.contributor.author | Justesen, J. | - |
dc.contributor.author | Kelve, M. | - |
dc.contributor.author | Uriz, María Jesús | - |
dc.date.accessioned | 2012-10-10T09:06:48Z | - |
dc.date.available | 2012-10-10T09:06:48Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Biochimie 91(11-12) : 1531-1534 (2009) | es_ES |
dc.identifier.issn | 0300-9084 | - |
dc.identifier.uri | http://hdl.handle.net/10261/57721 | - |
dc.description | 4 páginas, 1 tabla, 1 figura. | es_ES |
dc.description.abstract | Sponges [porifera], the most ancient metazoans, contain modules related to the vertebrate immune system, including the 2 0 ,5 0 -oligoadenylate synthetase (OAS). The components of the antiviral 2 0 ,5 0 -oligoadenylate (2–5A) system (OAS, 2 0 -Phosphodiesterase (2 0 -PDE) and RNAse L) of vertebrates have not all been identified in sponges. Here, we demonstrate for the first time that in addition to the OAS activity, sponges possess a 2 0 -PDE activity, which highlights the probable existence of a premature 2–5A system. Indeed, Suberites domuncula and Crella elegans exhibited this 2–5A degrading activity. Upon this finding, two out of three elements forming the 2–5A system have been found in sponges, only a endoribonuclease, RNAse L or similar, has to be found. We suspect the existence of a complex immune system in sponges, besides the self/non-self recognition system and the use of phagocytosis and secondary metabolites against pathogens. | es_ES |
dc.description.sponsorship | This work was supported by the European Union with the Marie Curie Research Training Network, BIOCAPITAL FP6 and by the Spanish Government with the project MARMOL, CI-CYT: CTM2007- 66635-CO2. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | 2'-phosphodiesterase | es_ES |
dc.subject | Activity | es_ES |
dc.subject | Sponge | es_ES |
dc.subject | Oligoadenylate synthetase | es_ES |
dc.title | 2′-phosphodiesterase and 2′,5′-oligoadenylate synthetase activities in the lowest metazoans, sponge [porifera] | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.biochi.2009.07.015 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.biochi.2009.07.015 | es_ES |
dc.identifier.e-issn | 1638-6183 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
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