Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/57533
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis |
Autor: | Martínez-Martín, Nuria CSIC ORCID; Fernández-Arenas, Elena CSIC; Delgado, Pilar CSIC ORCID; Bustelo, Xosé R. CSIC ORCID ; Alarcón, Balbino CSIC ORCID | Palabras clave: | Immunological synapse T cell receptor |
Fecha de publicación: | 26-ago-2011 | Editor: | Elsevier | Citación: | Immunity 35(2): 208–222 (2011) | Resumen: | The immunological synapse (IS) serves a dual role for sustained T cell receptor (TCR) signaling and for TCR downregulation. TC21 (Rras2) is a RRas subfamily GTPase that constitutively associates with the TCR and is implicated in tonic TCR signaling by activating phosphatidylinositol 3-kinase. In this study, we demonstrate that TC21 both cotranslocates with the TCR to the IS and is necessary for TCR internalization from the IS through a mechanism dependent on RhoG, a small GTPase previously associated with phagocytosis. Indeed, we found that the TCR triggers T cells to phagocytose 1–6 μm beads through a TC21- and RhoG-dependent pathway. We further show that TC21 and RhoG are necessary for the TCR-promoted uptake of major histocompatibility complex (MHC) from antigen-presenting cells. Therefore, TC21 and RhoG dependence underlie the existence of a common phagocytic mechanism that drives TCR internalization from the IS together with its peptide-MHC ligand. | Versión del editor: | http://dx.doi.org/10.1016/j.immuni.2011.06.003 | URI: | http://hdl.handle.net/10261/57533 | DOI: | 10.1016/j.immuni.2011.06.003 | ISSN: | 1074-7613 | E-ISSN: | 1097-4180 |
Aparece en las colecciones: | (IBMCC) Artículos (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
101
checked on 10-abr-2024
SCOPUSTM
Citations
140
checked on 23-abr-2024
WEB OF SCIENCETM
Citations
135
checked on 26-feb-2024
Page view(s)
396
checked on 24-abr-2024
Download(s)
104
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.