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Title

T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis

AuthorsMartínez-Martín, Nuria ; Fernández-Arenas, Elena ; Delgado, Pilar ; Bustelo, Xosé R. ; Alarcón, Balbino
KeywordsImmunological synapse
T cell receptor
Issue Date26-Aug-2011
PublisherElsevier
CitationImmunity 35(2): 208–222 (2011)
AbstractThe immunological synapse (IS) serves a dual role for sustained T cell receptor (TCR) signaling and for TCR downregulation. TC21 (Rras2) is a RRas subfamily GTPase that constitutively associates with the TCR and is implicated in tonic TCR signaling by activating phosphatidylinositol 3-kinase. In this study, we demonstrate that TC21 both cotranslocates with the TCR to the IS and is necessary for TCR internalization from the IS through a mechanism dependent on RhoG, a small GTPase previously associated with phagocytosis. Indeed, we found that the TCR triggers T cells to phagocytose 1–6 μm beads through a TC21- and RhoG-dependent pathway. We further show that TC21 and RhoG are necessary for the TCR-promoted uptake of major histocompatibility complex (MHC) from antigen-presenting cells. Therefore, TC21 and RhoG dependence underlie the existence of a common phagocytic mechanism that drives TCR internalization from the IS together with its peptide-MHC ligand.
Publisher version (URL)http://dx.doi.org/10.1016/j.immuni.2011.06.003
URIhttp://hdl.handle.net/10261/57533
DOI10.1016/j.immuni.2011.06.003
ISSN1074-7613
E-ISSN1097-4180
Appears in Collections:(IBMCC) Artículos
(CBM) Artículos
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