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Ambient pH gene regulation in fungi: making connections

AuthorsPeñalva, Miguel Ángel CSIC ORCID ; Tilburn, Joan; Bignell, Elaine; Arst, Herbert Nathan Jr. CSIC ORCID
Issue DateJun-2008
CitationTrends in Microbiology 16(6):291-300(2008)
AbstractMany fungi grow over a wide pH range and their gene expression is tailored to the environmental pH. In Aspergillus nidulans, the transcription factor PacC, an activator of genes expressed in alkaline conditions and a repressor of those expressed in acidic conditions, undergoes two processing proteolyses, the first being pH-signal dependent and the second proteasomal. Signal transduction involves a 'go-between' connecting two complexes, one of which comprises two plasma membrane proteins and an arrestin and the other comprises PacC, a cysteine protease, a scaffold and endosomal components. The Saccharomyces cerevisiae PacC orthologue, Rim101p, differs in that it does not undergo the second round of proteolysis and it functions directly as a repressor only. PacC/Rim101-mediated pH regulation is crucial to fungal pathogenicity
Description10 páginas, 3 figuras, I figura, 1 tabla -- PAGS nros. 291-300
Publisher version (URL)http://dx.doi.org/10.1016/j.tim.2008.03.006
Appears in Collections:(CIB) Artículos
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