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Role of loop 9 on the function of neuronal nicotinic receptors

AuthorsCriado, Manuel CSIC ORCID; Castillo, Mar; Mulet Soler, José; Sala, Francisco; Sala, Salvador
Issue Date2010
CitationBiochimica et Biophysica Acta - Biomembranes 1798(3): 654- 659 (2010)
AbstractWe have studied the role of loop 9 in the function of neuronal nicotinic receptors. By systematically mutating the residues in the loop we have determined that the most important amino acids determining the coupling of binding to gating are the ones closer to the transmembrane region. Single mutations at location E173 in homomeric alpha 7 receptors destroyed their function by completely abolishing the current while preserving the expression at the membrane. In contrast, heteromeric receptor alpha 3 beta 4 with the same mutations retained some function. We conclude that loop 9 has a different role in the function of homomeric and heteromeric receptors. (C) 2009 Elsevier B.V. All rights reserved.
Identifiersdoi: 10.1016/j.bbamem.2009.12.013
issn: 0005-2736
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