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Biochemical basis of resistance to hygromycin B in Streptomyces hygroscopicus - the producing organism

AuthorsPardo, José M. ; Malpartida Romero, Francisco; Rico, Manuel ; Jiménez Díaz, Antonio
Issue Date1985
PublisherSociety for General Microbiology
CitationJournal of General Microbiology 131: 1289- 1298 (1985)
AbstractHygromycin B, an aminocyclitol antibiotic that strongly inhibits both 70sand 80s ribosomes, is synthesized by Streptomyces hygroscopicus. Ribosomes from this Gram-positive mycelial bacterium are inhibited in vitro by the antibiotic. In contrast, the streptomycete is highly resistant to the drug in vivo since it possesses hygromycin B phosphotransferase activity. This enzyme has been shown by gel filtration to have a molecular weight of 42000,and to modify its antibiotic substrate to produce 7>-O-phosphoryl-hygromycinB which totally lacks biological activity both in vivo and in vitro.
Identifiersdoi: 10.1099/00221287-131-6-1289
issn: 0022-1287
Appears in Collections:(IRNAS) Artículos
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