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| Título: | Arabidopsis Synaptotagmin 1 is required for the maintenance of plasma membrane integrity and cell viability |
Autor: | López-Cobollo, Rosa María; Salinas, Julio CSIC ORCID ; Valpuesta, Victoriano; Botella, Miguel Angel | Fecha de publicación: | dic-2008 | Editor: | American Society of Plant Biologists | Citación: | Plant Cell 20(12):3374-3388(2008) | Resumen: | Plasma membrane repair in animal cells uses synaptotagmin 7, a Ca2+-activated membrane fusion protein that mediates delivery of intracellular membranes to wound sites by a mechanism resembling neuronal Ca2+-regulated exocytosis. Here, we show that loss of function of the homologous Arabidopsis thaliana Synaptotagmin 1 protein (SYT1) reduces the viability of cells as a consequence of a decrease in the integrity of the plasma membrane. This reduced integrity is enhanced in the syt1-2 null mutant in conditions of osmotic stress likely caused by a defective plasma membrane repair. Consistent with a role in plasma membrane repair, SYT1 is ubiquitously expressed, is located at the plasma membrane, and shares all domains characteristic of animal synaptotagmins (i.e., an N terminus-transmembrane domain and a cytoplasmic region containing two C2 domains with phospholipid binding activities). Our analyses support that membrane trafficking mediated by SYT1 is important for plasma membrane integrity and plant fitness | Descripción: | 15 páginas, 6 figuras.-- et al. | Versión del editor: | http://dx.doi.org/10.1105/tpc.108.063859 | URI: | http://hdl.handle.net/10261/57012 | DOI: | 10.1105/tpc.108.063859 | ISSN: | 1040-4651 | E-ISSN: | 1532-298X |
| Aparece en las colecciones: | (CIB) Artículos (INIA) Artículos |
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