English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/5700
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Adult olfactory bulbs from primates provide reliable ensheathing glia for cell therapy

AutorRubio Rodríguez, María Paz; Muñoz-Quiles, Cintia ; Ramón-Cueto, Almudena
Palabras clavelifespan
monkey
neural regeneration
senescence
long-term culture
p75
Fecha de publicación31-ene-2008
EditorWiley-Liss
CitaciónGlia 56 (5): 539-551 (2008)
ResumenOlfactory bulb ensheathing glia (OB-OEG) from adult rodents promote functional and morphological repair after grafting into injured spinal cords. To provide insight into the feasibility of using OB-OEG in human therapy, we studied OB-OEG in primates to determine their suitability for spinal cord transplantation. Here we show that OEG can be obtained from olfactory bulbs of adult macaca mulatta and nemestrina monkeys and compare their characteristics to those obtained from rats. In contrast to rodent OBOEG, primate OB-OEG are non-senescent, exhibit a longer lifespan, are less sensitive to high oxygen culture environment, and maintain a phenotype suitable for grafting for up to 2.5 months in vitro. Three-week cultures (short term) derived from a single macaca olfactory bulb provide enough OEG for autologous transplantation at the acute stage of injury, and after long-term cultures (2.5 months) may yield an additional 20 billion. OEG can be frozen for later use. Therefore, primate adult olfactory bulbs constitute a reliable source of OEG for cell therapy, and successful culture of these cells make autologous transplantation feasible.
DescripciónThe definitive version is available at http://www3.interscience.wiley.com/cgi-bin/fulltext/117905156/PDFSTART
Versión del editorhttp://dx.doi.org/10.1002/glia.20635
URIhttp://hdl.handle.net/10261/5700
DOI10.1002/glia.20635
Aparece en las colecciones: (IBV) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.