English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/5700
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Citado 29 veces en Web of Knowledge®  |  Pub MebCentral Ver citas en PubMed Central  |  Ver citas en Google académico
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar otros formatos: Exportar EndNote (RIS)Exportar EndNote (RIS)Exportar EndNote (RIS)
Título : Adult olfactory bulbs from primates provide reliable ensheathing glia for cell therapy
Autor : Rubio Rodríguez, María Paz; Muñoz-Quiles, Cintia ; Ramón-Cueto, Almudena
Palabras clave : lifespan
monkey
neural regeneration
senescence
long-term culture
p75
Fecha de publicación : 31-ene-2008
Editor: Wiley-Liss
Citación : Glia 56 (5): 539-551 (2008)
Resumen: Olfactory bulb ensheathing glia (OB-OEG) from adult rodents promote functional and morphological repair after grafting into injured spinal cords. To provide insight into the feasibility of using OB-OEG in human therapy, we studied OB-OEG in primates to determine their suitability for spinal cord transplantation. Here we show that OEG can be obtained from olfactory bulbs of adult macaca mulatta and nemestrina monkeys and compare their characteristics to those obtained from rats. In contrast to rodent OBOEG, primate OB-OEG are non-senescent, exhibit a longer lifespan, are less sensitive to high oxygen culture environment, and maintain a phenotype suitable for grafting for up to 2.5 months in vitro. Three-week cultures (short term) derived from a single macaca olfactory bulb provide enough OEG for autologous transplantation at the acute stage of injury, and after long-term cultures (2.5 months) may yield an additional 20 billion. OEG can be frozen for later use. Therefore, primate adult olfactory bulbs constitute a reliable source of OEG for cell therapy, and successful culture of these cells make autologous transplantation feasible.
Descripción : The definitive version is available at http://www3.interscience.wiley.com/cgi-bin/fulltext/117905156/PDFSTART
Versión del editor: http://dx.doi.org/10.1002/glia.20635
URI : http://hdl.handle.net/10261/5700
DOI: 10.1002/glia.20635
Aparece en las colecciones: (IBV) Artículos
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Mostrar el registro completo
 



NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.