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Title

Autophagy during vertebrate development

AuthorsRodríguez Aburto, María ; Hurlé, Juan M.; Varela-Nieto, Isabel ; Magariños, Marta
KeywordsAutophagy
Development
Proliferation
Apoptosis
Cell differentiation
Homeostasis
Aging
Issue Date2-Aug-2012
CitationCells
AbstractAutophagy is an evolutionarily conserved catabolic process by which cells degrade their own components through the lysosomal machinery. In physiological conditions, the mechanism is tightly regulated and contributes to maintain a balance between synthesis and degradation in cells undergoing intense metabolic activities. Autophagy is associated with major tissue remodeling processes occurring through the embryonic, fetal and early postnatal periods of vertebrates. Here we survey current information implicating autophagy in cellular death, proliferation or differentiation in developing vertebrates. In developing systems, activation of the autophagic machinery could promote different outcomes depending on the cellular context. Autophagy is thus an extraordinary tool for the developing organs and tissues.
Publisher version (URL)http://dx.doi.org/10.3390/cells1030428
URIhttp://hdl.handle.net/10261/56464
DOI10.3390/cells1030428
E-ISSN2073-4409
Appears in Collections:(IIBM) Artículos
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