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Focal adhesion kinase functions downstream of Sema3A signaling during axonal remodeling

AuthorsChacón, Mariola R.; Esteban Fernández, Gloria; Rico, Beatriz
Issue DateMay-2010
PublisherAcademic Press
CitationMolecular and Cellular Neuroscience - MCN 44(1): 30-42 (2010)
AbstractAxon refinement is a necessary event for sculpting the final wiring of neural circuits. Although some factors have been identified that cause axonal arbor remodeling, the molecular pathways transducing these extracellular signals to adhesion disassembly and the cytoskeleton are poorly understood. Here we show that conditional ablation of Focal adhesion kinase (Fak) abolishes axon remodeling induced by Semaphorin-3A (Sema3A) in hippocampal neurons. Sema3A elicits divergent effects on different tyrosine residues of FAK: it increases phosphorylation of Tyr397, the kinase domain and the tyrosine residue 925, and decreases phosphorylation of Tyr407 and Tyr861. Moreover, Sema3A mediates mechanisms that contribute to the disassembly of adhesion contacts in a FAK-dependent manner: tyrosine phosphorylation of α-actinin and FAKY925 that decreases FAK-Paxillin interaction. Altogether, our results provide novel insights into the spatiotemporal dynamics of FAK activation mediated by Sema3A and on its interaction with its downstream effectors: Paxillin and α-actinin in neurons.
Description13 p., 9 figures and references.
Publisher version (URL)http://dx.doi.org/10.1016/j.mcn.2010.02.001
Appears in Collections:(IN) Artículos
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