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On the mechanism of inhibition of p27 degradation by 15-deoxy-Δ12,14-prostaglandin J 2 in lymphoblasts of Alzheimer’s disease patients

AuthorsMuñoz, Úrsula ; Bartolomé Robledo, Fernando ; Esteras, Noemí ; Bermejo-Pareja, Félix; Martín-Requero, Ángeles
KeywordsAlzheimer’s disease
cell survival
Issue Date2008
CitationCellular and Molecular Life Sciences 65(21):3507-35119(2008)
AbstractWe have analyzed the intracellular signals that allow lymphoblasts from Alzheimer’s disease (AD) patients to escape from serum deprivation-induced apoptosis. The following observations suggested that modulation of ERK1/2 activity by Ca2+/calmodulin (CaM) is involved in preventing apoptosis: (i) ERK1/2 activity seems to support lethality in control cells, as PD98059, the inhibitor of the activating MEK prevented cell death; (ii) control cells show a persistent and higher stimulation of ERK1/2 than that of AD cells in the absence of serum; (iii) CaM antagonists have no effects on control cells, but sensitize AD cells to death induced by serum withdrawal and increased ERK1/2 phosphorylation, and (iv) no apoptotic effects of CaM antagonists were observed in AD cells treated with PD98059. These results suggest the existence of an activation threshold of the ERK1/2 pathway setting by Ca2+/CaM-dependent mechanisms, which appears to be the critical factor controlling cell survival or death decision under trophic factor withdrawal
Description13 páginas, 10 figuras -- PAGS nros. 3507-3519
Publisher version (URL)http:dx.doi.org/10.1007/s00018-008-8411-9
Appears in Collections:(CIB) Artículos
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