English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/56061
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Multiple timescale encoding of slowly varying whisker stimulus envelope in cortical and thalamic neurons in vivo

AuthorsLundstrom, Brian Nils; Fairhall, Adrienne L.; Maravall, Miguel
Issue DateApr-2010
PublisherSociety for Neuroscience
CitationJournal of Neuroscience 30(14): 5071-5077 (2010)
AbstractAdaptive processes over many timescales endow neurons with sensitivity to stimulus changes over a similarly wide range of scales. Although spike timing of single neurons can precisely signal rapid fluctuations in their inputs, the mean firing rate can convey information about slower-varying properties of the stimulus. Here, we investigate the firing rate response to a slowly varying envelope of whisker motion in two processing stages of the rat vibrissa pathway. The whiskers of anesthetized rats were moved through a noise trajectory with an amplitude that was sinusoidally modulated at one of several frequencies. In thalamic neurons, we found that the rate response to the stimulus envelope was also sinusoidal, with an approximately frequency-independent phase advance with respect to the input. Responses in cortex were similar but with a phase shift that was about three times larger, consistent with a larger amount of rate adaptation. These response properties can be described as a linear transformation of the input for which a single parameter quantifies the phase shift as well as the degree of adaptation. These results are reproduced by a model of adapting neurons connected by synapses with short-term plasticity, showing that the observed linear response and phase lead can be built up from a network that includes a sequence of nonlinear adapting elements. Our study elucidates how slowly varying envelope information under passive stimulation is preserved and transformed through the vibrissa processing pathway.
Description7 p., 5 figures and references
Publisher version (URL)http://dx.doi.org/10.1523/JNEUROSCI.2193-09.2010
URIhttp://hdl.handle.net/10261/56061
DOI10.1523/JNEUROSCI.2193-09.2010
E-ISSN1529-2401
Appears in Collections:(IN) Artículos
Files in This Item:
File Description SizeFormat 
Multiple timescale encoding of slowly varying.pdf968,3 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.