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Thiolato gold(I) complexes containing water-soluble phosphane ligands: a characterization of their chemical and biological properties

AuthorsVergara, Elena; Cerrada, Elena ; Laguna, Mariano
Issue Date2011
PublisherRoyal Society of Chemistry (UK)
CitationDalton Transactions 40(41): 10927-10935 (2011)
AbstractA series of thiolate gold(I) derivatives bearing water soluble phosphanes – namely sodium triphenylphosphane monosulfonate (TPPMS), sodium triphenylphosphane trisulfonate (TPPTS), 1,3,5-triaza-7-phosphaadamantane (PTA) and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane (DAPTA) – is reported and the compounds studied for their luminescence properties in the solid state. Two of these derivatives, [Au(SMe2pyrim)(PTA)] and [Au(SBenzoxazole)(DAPTA)], are also structurally characterized by X-ray diffraction analysis. Strong antiproliferative effects are observed for most of the compounds in the human ovarian carcinoma cell lines (A2780/S) and its cisplatin-resistant variant (A2780/R), which depend on both the type of thiolate and phosphane ligands. ICP-MS studies were also performed to evaluate the influence of the gold uptake on the cytotoxic potency of the compounds.
Description9 páginas, 3 figuras, 5 tablas, 1 esquema.-- et al.
Publisher version (URL)http://dx.doi.org/10.1039/C1DT10892A
Appears in Collections:(ISQCH) Artículos
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