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Título: | Triacylglycerol-rich lipoproteins trigger the phosphorylation of extracellular-signal regulated kinases in vascular cells |
Autor: | Pacheco, Yolanda M. CSIC ORCID; Abia, Rocío CSIC ORCID ; Perona, Javier S. CSIC ORCID ; Meier, Kathryn E.; Montero Romero, Emilio; Ruiz-Gutiérrez, Valentina CSIC ; Muriana, Francisco J. G. CSIC ORCID | Palabras clave: | Triacylglycerol-rich lipoproteins Vascular cells Mitogen-activated protein kinase Proliferation Atherosclerosis |
Fecha de publicación: | 9-ago-2002 | Editor: | Elsevier | Citación: | Life Sciences 71(12): 1351-1360 (2002) | Resumen: | Postprandial triacylglycerol-rich lipoproteins (TRL) have been implicated in the pathophysiology of atherosclerosis, but the intracellular processes by which TRL could affect vascular function are still unknown. Incubation of TRL obtained at 2 h postprandial period with vascular smooth muscle cells (VSMC) produced a tyrosine phosphorylation of the extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2) that belong to the mitogen-activated protein kinase (MAPK) family. The activation of ERK1 and ERK2 had a maximum at 15 min, returned to baseline by 60 min, and was partially depleted after incubation of cells with a MAPKK inhibitor (PD 098059). In addition, postprandial TRL did competent VSMC for DNA replication through a MAPK pathway. These effects were dependent of the lipid composition of TRL. Our observations suggest that postprandial TRL can trigger activation of the MAPK pathway and induce a mitogenic response in VSMC in a lipid-dependent fashion. | Versión del editor: | http://dx.doi.org/10.1016/S0024-3205(02)01860-X | URI: | http://hdl.handle.net/10261/55909 | DOI: | 10.1016/S0024-3205(02)01860-X | ISSN: | 0024-3205 |
Aparece en las colecciones: | (IG) Artículos |
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