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Título: | Sphingosine 1-phosphate signal survival and mitogenesis are mediated by lipid-stereospecific binding of triacylglycerol-rich lipoproteins |
Autor: | Pacheco, Yolanda M. CSIC ORCID; Abia, Rocío CSIC ORCID ; Olivera, A.; Spiegel, S.; Ruiz-Gutiérrez, Valentina CSIC ; Muriana, Francisco J. G. CSIC ORCID | Palabras clave: | Sphingolipid VSMC Triacylglycerol-rich lipoprotein Postprandial metabolism |
Fecha de publicación: | dic-2003 | Editor: | Birkhäuser Verlag | Citación: | Cellular and Molecular Life Sciences 60(12): 2757-2766 (2003) | Resumen: | Proof for the role of triacylglycerol-rich lipoproteins (TRLs) in the development of cardiovascular events is accumulating. We recently reported that postprandial TRLs bind to and internalize into human aortic vascular smooth muscle cells (HA-VSMCs) by a lipid-dependent mechanism. We now show that postprandial TRLs triggered hydrolysis of sphingomyelin and stimulation of the sphingosine kinase producing sphingosine 1-phosphate (S1P). In addition, postprandial TRLs exhibited survival and mitogenic effects. Interestingly, the signals were modulated by the nature of the fatty acids located at the sn-2 position in the triacylglycerol molecules of TRL. This lipid-stereospecific regulation of S1P cellular levels in HA-VSMCs provides a novel insight into the intrinsic role of dietary fatty acids and the mechanism mediated by triacylglycerol-containing postprandial lipoproteins in the pathogenesis of atherosclerosis. | Versión del editor: | http://dx.doi.org/10.1007/s00018-003-3323-1 | URI: | http://hdl.handle.net/10261/55888 | DOI: | 10.1007/s00018-003-3323-1 | ISSN: | 1420-682X | E-ISSN: | 1420-9071 |
Aparece en las colecciones: | (IG) Artículos |
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