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http://hdl.handle.net/10261/55777
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dc.contributor.author | Urpi-Sarda, Mireia | - |
dc.contributor.author | Casas, Rosa | - |
dc.contributor.author | Chiva-Blanch, Gemma | - |
dc.contributor.author | Romero-Mamani, Edwin Saúl | - |
dc.contributor.author | Valderas-Martínez, Palmira | - |
dc.contributor.author | Salas-Salvadó, Jordi | - |
dc.contributor.author | Covas, María Isabel | - |
dc.contributor.author | Toledo, Estefanía | - |
dc.contributor.author | Andrés-Lacueva, Cristina | - |
dc.contributor.author | Llorach, Rafael | - |
dc.contributor.author | García-Arellano, Ana | - |
dc.contributor.author | Bulló, Mònica | - |
dc.contributor.author | Ruiz-Gutiérrez, Valentina | - |
dc.contributor.author | Lamuela-Raventós, Rosa M. | - |
dc.contributor.author | Estruch, Ramón | - |
dc.date.accessioned | 2012-09-07T08:53:35Z | - |
dc.date.available | 2012-09-07T08:53:35Z | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | Journal of Nutrition 142(6): 1019-1025 (2012) | es_ES |
dc.identifier.issn | 0022-3166 | - |
dc.identifier.other | PMID: 22535754 | - |
dc.identifier.uri | http://hdl.handle.net/10261/55777 | - |
dc.description.abstract | Adherence to a Mediterranean diet (MD) is associated with a reduced risk of coronary heart disease. However, the molecular mechanisms involved are not fully understood. The aim of this study was to compare the effects of 2 MD with those of a low-fat-diet (LFD) on circulating inflammatory biomarkers related to atherogenesis. A total of 516 participants included in the Prevention with Mediterranean Diet Study were randomized into 3 intervention groups [MD supplemented with virgin olive oil (MD-VOO); MD supplemented with mixed nuts (MD-Nuts); and LFD]. At baseline and after 1 y, participants completed FFQ and adherence to MD questionnaires, and plasma concentrations of inflammatory markers including intercellular adhesion molecule-1(ICAM-1), IL-6, and 2 TNF receptors (TNFR60 and TNFR80) were measured by ELISA. At 1 y, the MD groups had lower plasma concentrations of IL-6, TNFR60, and TNFR80 (P < 0.05), whereas ICAM-1, TNFR60, and TNFR80 concentrations increased in the LFD group (P < 0.002). Due to between-group differences, participants in the 2 MD groups had lower plasma concentrations of ICAM-1, IL-6, TNFR60, and TNFR80 compared to those in the LFD group (P ≤ 0.028). When participants were categorized in tertiles of 1-y changes in the consumption of selected foods, those in the highest tertile of virgin olive oil (VOO) and vegetable consumption had a lower plasma TNFR60 concentration compared with those in tertile 1 (P < 0.02). Moreover, the only changes in consumption that were associated with 1-y changes in the geometric mean TNFR60 concentrations were those of VOO and vegetables (P = 0.01). This study suggests that a MD reduces TNFR concentrations in patients at high cardiovascular risk. | es_ES |
dc.description.sponsorship | Supported by the Spanish Ministry of Science and Innovation (MICINN): AGL2009-13906-C02-02 and AGL2010-22319-C03-02; Instituto de Salud Carlos III: PI10/01407, G03/140, CIBEROBN, RD06/0045, European Union, and a “Sara Borrell” postdoctoral program (M.U.-S.; Ref: CD09/00134). CIBER OBN is an initiative of the Instituto de Salud Carlos III. G.C-B. was the recipient of a Manuel de Oya fellowship; P.V-M. thanks the APIF predoctoral fellowship from the University of Barcelona. R.L. thanks the “Ramon y Cajal” program (MICINN) and Fondo Social Europeo. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Nutrition | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Intercellular adhesion molecule 1 | es_ES |
dc.subject | Inteleukin 6 | es_ES |
dc.subject | Virgin olive oil | es_ES |
dc.subject | Tumor necrosis factor receptor | es_ES |
dc.subject | Cardiovascular risks | es_ES |
dc.subject | Cardiovascular diseases | es_ES |
dc.title | The Mediterranean Diet Pattern and Its Main Components Are Associated with Lower Plasma Concentrations of Tumor Necrosis Factor Receptor 60 in Patients at High Risk for Cardiovascular Disease | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.3945/jn.111.148726 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.3945/jn.111.148726 | es_ES |
dc.identifier.e-issn | 1541-6100 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
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