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Título: | Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells |
Autor: | Márquez-Martín, Ana CSIC; Puerta, Rocío de la; Fernández-Arche, Ángeles; Ruiz-Gutiérrez, Valentina CSIC ; Yaqoob, Parveen | Palabras clave: | Olive pomace oil Pentacycli triterpene Peripheral blood mononuclear cells Cytokines Inflammation |
Fecha de publicación: | dic-2006 | Editor: | Elsevier | Citación: | Cytokine 36(5-6): 211-217 (2006) | Resumen: | Olive pomace oil, also known as “orujo” olive oil, is a blend of refined-pomace oil and virgin olive oil, fit for human consumption. Maslinic acid, oleanolic acid, erythrodiol, and uvaol are pentacyclic triterpenes, found in the non-glyceride fraction of orujo oil, which have previously been reported to have anti-inflammatory properties. In the present work, we investigated the effect of these minor components on pro-inflammatory cytokine production by human peripheral blood mononuclear cells in six different samples. Uvaol, erythrodiol, and oleanolic acid significantly decreased IL-1β and IL-6 production in a dose-dependent manner. All three compounds significantly reduced TNF-α production at 100 μM; however, at 10 μM, uvaol and oleanolic acid enhanced the generation of TNF-α. In contrast, maslinic acid did not significantly alter the concentration of those cytokines, with the exception of a slight inhibitory effect at 100 μM. All four triterpenes inhibited production of I-309, at 50 μM and 100 μM. However, uvaol enhanced I-309 production at 10 μM. The triterpenic dialcohols had a similar effect on MIG production. In conclusion, this study demonstrates that pentacyclic triterpenes in orujo oil exhibit pro- and anti-inflammatory properties depending on chemical structure and dose, and may be useful in modulating the immune response. | Versión del editor: | http://dx.doi.org/10.1016/j.cyto.2006.12.007 | URI: | http://hdl.handle.net/10261/55708 | DOI: | 10.1016/j.cyto.2006.12.007 | ISSN: | 1043-4666 |
Aparece en las colecciones: | (IG) Artículos |
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