Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/55494COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Título: | Prevalence of CYP2C9 polymorphisms in the south of EuropePrevalence of CYP2C9 polymorphisms in Europe |
Autor: | Sánchez-Diz, Paula; Velasco, Eladio CSIC ORCID | Fecha de publicación: | oct-2009 | Editor: | Nature Publishing Group | Citación: | Pharmacogenomics Journal 9(5): 306-310 (2009) | Resumen: | CYP2C9 is a major liver enzyme responsible of the metabolism of many clinically important drugs. The presence of CYP2C9 genetic polymorphisms has been associated with marked interindividual variability in its catalytic activity that could result in drug toxicity. Here we present frequencies of the most common CYP2C9 coding variants CYP2C9*2 (C430T) and CYP2C9*3 (A1075C) in representative samples of four regions from Spain (Basque Country, n=358; Catalonia, n=240; Central Spain, n=190 and Galicia, n=288) and one northern Italian region, (Verona, n=164), which range between 0.125 and 0.165 in the case of CYP2C9*2 and between 0.071 and 0.085 for CYP2C9*3. No significant differences between CYP2C9 allele frequencies were found comparing all the sampled populations. A more extensive comparative analysis using allele frequency data of populations widely spread over Europe was performed, showing significant differences in the CYP2C9*2 allele frequencies distribution between some of the regions, being quite homogeneous in the case of CYP2C9*3 variant. The results obtained show that above 40% of our samples carry a mutate allele, which can result in a poor metabolization of low therapeutic index drugs as oral anticoagulants (warfarin, acenocoumarol), oral antidiabetic drugs and some non-steroidal anti-inflammatory drugs. Our study constitutes both a large (n=1240) and robust allele frequency database on CYP2C9 polymorphisms, which represents one of the most numerous CYP2C9*2 and *3 database existing to date. | Descripción: | 5 páginas.-- et al. | Versión del editor: | http://dx.doi.org/10.1038/tpj.2009.16 | URI: | http://hdl.handle.net/10261/55494 | DOI: | 10.1038/tpj.2009.16 | ISSN: | 1470-269X | E-ISSN: | 1473-1150 |
| Aparece en las colecciones: | (IBGM) Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| accesoRestringido.pdf | 15,38 kB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
26
checked on 12-abr-2024
WEB OF SCIENCETM
Citations
22
checked on 27-feb-2024
Page view(s)
307
checked on 19-abr-2024
Download(s)
73
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.