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Exploring the Links between Natural Products and Bacterial Assemblages in the Sponge Aplysina aerophoba .
|Authors:||Sacristán-Soriano, Oriol ; Banaigs, Bernard; Casamayor, Emilio O. ; Becerro, Mikel|
|Publisher:||American Society for Microbiology|
|Citation:||applied and environmental microbiology 77(3) : 862-870 (2011)|
|Abstract:||The sponge Aplysina aerophoba produces a large diversity of brominated alkaloids (BAs) and hosts a complex microbial assemblage. Although BAs are located within sponge cells, the enzymes that bind halogen elements to organic compounds have been exclusively described in algae, fungi, and bacteria. Bacterial communities within A. aerophoba could therefore be involved in the biosynthesis of these compounds. This study investigates whether changes in both the concentration of BAs and the bacterial assemblages are correlated in A. aerophoba. To do so, we quantiﬁed major natural products using high-performance liquid chromatography and analyzed bacterial assemblages using denaturing gradient gel electrophoresis on the 16S rRNA gene. We identiﬁed multiple associations between bacteria and natural products, including a strong relationship between a Chloroﬂexi phylotype and aplysinamisin-1 and between an unidentiﬁed bacterium and aerophobin-2 and isoﬁstularin-3. Our results suggest that these bacteria could either be involved in the production of BAs or be directly affected by them. To our knowledge, this is one of the ﬁrst reports that ﬁnd a signiﬁcant correlation between natural products and bacterial populations in any benthic organism. Further investigating these associations will shed light on the organization and functioning of host-endobiont systems such as Aplysina aerophoba.|
|Description:||9 páginas, 5 tablas, 4 figuras.|
|Publisher version (URL):||http://dx.doi.org/10.1128/AEM.00100-10|
|Appears in Collections:||(CEAB) Artículos|
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