English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/55066
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Reciprocal repression between Sox3 and Snail transcription factors defines embryonic territories at gastrulation

AuthorsAcloque, Hervé; Ocaña, Oscar H.; Matheu, Ander; Rizzoti, Karine; Wise, Clare; Lovell-Badge, Robin; Nieto, M. Ángela
Issue DateSep-2011
PublisherElsevier
CitationDevelopmental Cell 21(3): 546-558 (2011)
AbstractIn developing amniote embryos, the first epithelial-to-mesenchymal transition (EMT) occurs at gastrulation, when a subset of epiblast cells moves to the primitive streak and undergoes EMT to internalize and generate the mesoderm and the endoderm. We show that in the chick embryo this decision to internalize is mediated by reciprocal transcriptional repression of Snail2 and Sox3 factors. We also show that the relationship between Sox3 and Snail is conserved in the mouse embryo and in human cancer cells. In the embryo, Snail-expressing cells ingress at the primitive streak, whereas Sox3-positive cells, which are unable to ingress, ensure the formation of ectodermal derivatives. Thus, the subdivision of the early embryo into the two main territories, ectodermal and mesendodermal, is regulated by changes in cell behavior mediated by the antagonistic relationship between Sox3 and Snail transcription factors.
Description13 p., 8 figures and references.
Publisher version (URL)http://dx.doi.org/10.1016/j.devcel.2011.07.005
URIhttp://hdl.handle.net/10261/55066
DOI10.1016/j.devcel.2011.07.005
ISSN1534-5807
E-ISSN1878-1551
Appears in Collections:(IN) Artículos
Files in This Item:
File Description SizeFormat 
restringido.pdf21,67 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.