Characterization of a C3 and a factor B-like in the carpet-shell clam, Ruditapes decussatus

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Title:	Characterization of a C3 and a factor B-like in the carpet-shell clam, Ruditapes decussatus
Authors:	Prado-Álvarez, María ; Rotllant, Josep ; Gestal, C. ; Novoa, Beatriz ; Figueras Huerta, Antonio
Keywords:	Clam Ruditapes decussatus Complement C3 Factor B Gene expression
Issue Date:	2009
Publisher:	Elsevier
Citation:	Fish and Shellfish Immunology 26(2): 305-315 (2009)
Abstract:	The alternative pathway is considered to be the most ancient route for activation of the complement system. Herein, we report the characterization of C3 and factor B-like proteins in the clam Ruditapes decussatus, termed Rd-C3 and Rd-Bf-like. The Rd-C3 is a three-chain protein, similar to other protoC3 proteins, and the Rd-Bf-like is composed of two complement control protein modules (CCP domains) that differ from other described Bf proteins. The inoculation of clams with live bacteria did not result in induction of these functions, but inhibited the expression of Rd-C3 and Rd-Bf-like.
Description:	11 páginas, 7 figuras, 2 tablas
Publisher version (URL):	http://dx.doi.org/10.1016/j.fsi.2008.11.015
URI:	http://hdl.handle.net/10261/54968
DOI:	10.1016/j.fsi.2008.11.015
ISSN:	1050-4648
Appears in Collections:	(IIM) Artículos

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