English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/54493
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorBaragaña, B.-
dc.contributor.authorMcCarthy, O.-
dc.contributor.authorSánchez, Paula-
dc.contributor.authorBosch-Navarrete, C.-
dc.contributor.authorKaiser, M.-
dc.contributor.authorBrun, R.-
dc.contributor.authorWhittingham, J. L.-
dc.contributor.authorRoberts, S. M.-
dc.contributor.authorZhou, X. X.-
dc.contributor.authorWilson, K. S.-
dc.contributor.authorJohansson, N. G.-
dc.contributor.authorGonzález-Pacanowska, D.-
dc.contributor.authorGilbert, I. H.-
dc.identifierdoi: 10.1016/j.bmc.2011.02.012-
dc.identifierissn: 0968-0896-
dc.identifier.citationBioorganic and Medicinal Chemistry 19: 2378- 2391 (2011)-
dc.description.abstractWe report a series of β-branched acyclic tritylated deoxyuridine analogues as inhibitors of Plasmodium falciparum deoxyuridine-5′- triphosphate nucleotidohydrolase (PfdUTPase), an enzyme involved in nucleotide metabolism that acts as first line of defence against uracil incorporation into DNA. Compounds were assayed against both PfdUTPase and intact parasites showing a correlation between enzyme inhibition and cellular assays. β-Branched acyclic uridine analogues described here showed equal or slightly better potency and selectivity compared with previously reported analogues. The best inhibitor gave a Ki of 0.5 μM against PfdUTPase with selectivity greater than 200-fold compared to the corresponding human enzyme and sub-micromolar growth inhibition of P. falciparum (EC50 0.6 μM). A crystal structure of the complex of PfdUTPase with one of the inhibitors shows that this acyclic derivative binds to the active site in a similar manner to that previously reported for a tritylated cyclic deoxyuridine derivative. © 2011 Elsevier Ltd. All rights reserved.-
dc.publisherPergamon Press-
dc.titleβ-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase-
dc.description.versionPeer Reviewed-
Appears in Collections:(IPBLN) Artículos
Files in This Item:
There are no files associated with this item.
Show simple item record

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.