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Title

Role of Klebsiella pneumoniae OmpK35 porin in antimicrobial resistance

AuthorsDoménech-Sánchez, Antonio; Martínez-Martínez, Luis; Hernández-Allés, Santiago; Conejo, María del Carmen; Pascual, Álvaro; Tomás, Juan M.; Albertí, Sebastián; Benedí Benito, Vicente Javier
Issue Date2003
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemotherapy 47: 3332- 3335 (2003)
AbstractOmpK35 from Klebsiella pneumoniae is the homologue of Escherichia coli OmpF porin. Expression of OmpK35 in K. pneumoniae strain CSUB10R (lacking both OmpK35 and OmpK36) decreased the MICs of cephalosporins and meropenem ≥128-fold and decreased the MICs of imipenem, ciprofloxacin, and chloramphenicol ≥8-fold. MIC reductions by OmpK35 were 4 times (cefepime), 8 times (cefotetan, cefotaxime, and cefpirome), or 128 times (ceftazidime) higher than those caused by OmpK36, but the MICs were similar or 1 dilution lower for other evaluated agents.
URIhttp://hdl.handle.net/10261/54221
DOI10.1128/AAC.47.10.3332-3335.2003
Identifiersdoi: 10.1128/AAC.47.10.3332-3335.2003
issn: 0066-4804
e-issn: 1098-6596
Appears in Collections:(IMEDEA) Artículos
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