Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/54181
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

A novel isoform of the Ly108 gene ameliorates murine lupus

AuthorsKeszei, Marton; Detre, Cynthia; Rietdijk, Svend T.; Muñoz, P.; Romero, Xavier; Berger, Scott B.; Calpe, Silvia; Liao, Gongxian; Castro, Wilson; Aimee, Julien; Wu, Jing Y.; Shin, Dong M.; Sancho, Jaime CSIC ORCID ; Zubiaur, Mercedes CSIC ORCID ; Morse, Herbert C.; Morel, Laurence; Engel, Pablo; Wang, Ninghai; Terhorst, Cox
Issue Date2011
PublisherRockefeller University Press
CitationJournal of Experimental Medicine 208: 811- 822 (2011)
AbstractStudies of human systemic lupus erythematosus patients and of murine congenic mouse strains associate genes in a DNA segment on chromosome 1 with a genetic predisposition for this disease. The systematic analysis of lupus-prone congenic mouse strains suggests a role for two isoforms of the Ly108 receptor in the pathogenesis of the disease. In this study, we demonstrate that Ly108 is involved in the pathogenesis of lupus-related autoimmunity in mice. More importantly, we identified a third protein isoform, Ly108-H1, which is absent in two lupus-prone congenic animals. Introduction of an Ly108-H1–expressing transgene markedly diminishes T cell–dependent autoimmunity in congenic B6.Sle1b mice. Thus, an immune response–suppressing isoform of Ly108 can regulate the pathogenesis of lupus.
URIhttp://hdl.handle.net/10261/54181
DOI10.1084/jem.20101653
Identifiersdoi: 10.1084/jem.20101653
issn: 0022-1007
Appears in Collections:(IPBLN) Artículos




Files in This Item:
File Description SizeFormat
A novel isoform.pdf2,13 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work

PubMed Central
Citations

35
checked on Jan 20, 2023

SCOPUSTM   
Citations

46
checked on Jan 24, 2023

WEB OF SCIENCETM
Citations

44
checked on Jan 21, 2023

Page view(s)

334
checked on Jan 27, 2023

Download(s)

362
checked on Jan 27, 2023

Google ScholarTM

Check

Altmetric

Altmetric


Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.