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Title

Synthesis of Oligonucleotide–Peptide Conjugates for Biomedical and Technological Applications

AuthorsAviñó, Anna ; Grijalvo, Santiago ; Pérez-Rentero, Sonia; Garibotti, Alejandra V. ; Terrazas, Montserrat ; Eritja Casadellà, Ramón
KeywordsDNA
RNA
Nucleic acids
RNA interference
Antisense
Oligonucleotide–peptide conjugates
Stepwise synthesis
Postsynthetic conjugation
Issue Date2001
PublisherHumana Press
CitationBioconjugation Protocol: Strategies and Methods : 223-238 (2011)
SeriesMethods in Molecular Biology
751
AbstractOligonucleotide–peptide conjugates have attracted considerable interest especially for biomedical uses. In the first part of this chapter, we describe protocols for the stepwise synthesis of oligonucleotides carrying peptide sequences at the 3¢-end on a single support. The resulting oligonucleotide–peptide conjugates may be used as exogenous effectors for the specific control of gene expression. In the second part of this chapter, detailed postsynthetic conjugation protocols to introduce peptide sequences into oligonucleotide sequences are also presented.
Publisher version (URL)http://www.dx.doi.org/10.1007/978-1-61779-151-2_14
URIhttp://hdl.handle.net/10261/54172
DOI10.1007/978-1-61779-151-2_14
ISBN978-1-61779-150-5
Appears in Collections:(IQAC) Libros y partes de libros
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