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Analysis of the REL polymorphism rs13031237 in autoimmune diseases.

AuthorsVaradé, J.; Palomino-Morales, Rogelio; Ortego-Centeno, N.; Díaz-Rubio, M.; Fernández-Gutiérrez, B.; González-Gay, M. A.; Pascual-Salcedo, Dora; Balsa, A.; Iglesias, A.; Gómez-García, M.; Witte, Torsten; Radstake, T. R.; Coenen, M. J.; Urcelay, Elena; Martín, J.
Issue Date2011
PublisherBMJ Publishing Group
CitationAnnals of the Rheumatic Diseases 70: 711- 712 (2011)
AbstractREL encodes the c-rel protein, a member of the nuclear factor-κB family of transcription factors involved in the autoimmune response via regulation of the expression of cytokines, anti-apoptotic molecules and cell cycle modulators.1 Expression of c-rel, which is restricted to mature haematopoietic cells, has been described in patients with systemic lupus erythematosus (SLE) and inflammatory bowel disease.2 3 Associations of the REL gene with celiac disease4 and rheumatoid arthritis (RA)5 have been reported. Moreover, Rel knockout mice do not develop autoimmune diseases such as experimental autoimmune encephalomyelitis,6 collagen-induced arthritis or type I diabetes.7
Identifiersdoi: 10.1136/ard.2010.134593
issn: 0003-4967
Appears in Collections:(IPBLN) Artículos
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