Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/54034
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Álvarez, Dolores | - |
dc.contributor.author | Merino, Santiago | - |
dc.contributor.author | Tomás, Juan M. | - |
dc.contributor.author | Benedí Benito, Vicente Javier | - |
dc.contributor.author | Albertí, Sebastián | - |
dc.date.accessioned | 2012-07-27T09:10:19Z | - |
dc.date.available | 2012-07-27T09:10:19Z | - |
dc.date.issued | 2000 | - |
dc.identifier | doi: 10.1128/IAI.68.2.953-955.2000 | - |
dc.identifier | issn: 0019-9567 | - |
dc.identifier.citation | Infection and Immunity 68: 953- 955 (2000) | - |
dc.identifier.uri | http://hdl.handle.net/10261/54034 | - |
dc.description.abstract | We have previously demonstrated the existence of Klebsiella pneumoniae clinical isolates deficient in the lipopolysaccharide O side chain, the major factor for resistance to complement-mediated killing in this bacterial species. These isolates are complement resistant, and their mechanisms to resist complement were investigated by selecting transposon-generated complement-sensitive mutants. One mutant with a drastically reduced capacity to grow in nonimmune human serum carried the transposon inserted in an open reading frame of a gene cluster involved in capsule synthesis. This mutant produced less capsule, bound more molecules of the complement component C3, and was more sensitive to complement-mediated and opsonophagocytic killings than was the parent strain. Four additional clinical isolates representing four different K serotypes were studied, and results showed that capsular polysaccharide is a major complement resistance factor in these O side chain- deficient isolates. | - |
dc.description.sponsorship | This work was supported by grants from the Comisio´n Interministerial de Ciencia y Tecnologı´a (CICYT) and project FEDER 2FD97- 0287. D.A. was supported by a predoctoral fellowship from CICYT. | - |
dc.language.iso | eng | - |
dc.publisher | American Society for Microbiology | - |
dc.rights | closedAccess | - |
dc.title | Capsular polysaccharide is a major complement resistance factor in lipopolysaccharide O side chain-deficient Klebsiella pneumoniae clinical isolates | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1128/IAI.68.2.953-955.2000 | - |
dc.date.updated | 2012-07-27T09:10:20Z | - |
dc.description.version | Peer Reviewed | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (IMEDEA) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
85
checked on 19-abr-2024
WEB OF SCIENCETM
Citations
81
checked on 29-feb-2024
Page view(s)
383
checked on 22-abr-2024
Download(s)
107
checked on 22-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.