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Title

Capsular polysaccharide is a major complement resistance factor in lipopolysaccharide O side chain-deficient Klebsiella pneumoniae clinical isolates

AuthorsÁlvarez, D.; Merino, Santiago ; Tomás, Juan M.; Benedí Benito, Vicente Javier; Albertí, Sebastián
Issue Date2000
PublisherAmerican Society for Microbiology
CitationInfection and Immunity 68: 953- 955 (2000)
AbstractWe have previously demonstrated the existence of Klebsiella pneumoniae clinical isolates deficient in the lipopolysaccharide O side chain, the major factor for resistance to complement-mediated killing in this bacterial species. These isolates are complement resistant, and their mechanisms to resist complement were investigated by selecting transposon-generated complement-sensitive mutants. One mutant with a drastically reduced capacity to grow in nonimmune human serum carried the transposon inserted in an open reading frame of a gene cluster involved in capsule synthesis. This mutant produced less capsule, bound more molecules of the complement component C3, and was more sensitive to complement-mediated and opsonophagocytic killings than was the parent strain. Four additional clinical isolates representing four different K serotypes were studied, and results showed that capsular polysaccharide is a major complement resistance factor in these O side chain- deficient isolates.
URIhttp://hdl.handle.net/10261/54034
DOI10.1128/IAI.68.2.953-955.2000
Identifiersdoi: 10.1128/IAI.68.2.953-955.2000
issn: 0019-9567
Appears in Collections:(IMEDEA) Artículos
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