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Homologue recognition during meiosis is associated with a change in chromatin conformation

AuthorsPrieto, Pilar ; Shaw, Peter; Moore, Graham
Issue DateSep-2004
PublisherNature Publishing Group
CitationNature Cell Biology 6, 906 - 908 (2004)
AbstractDuring meiosis, homologous chromosomes are sorted into pairs and are then intimately aligned, or synapsed, along their lengths while a proteinaceous structure, the synaptonemal complex, is assembled between them. However, little is known about how chromosomes first recognise each other1. Here we show, by comparing the behaviour of wild-type wheat and wheat mutant for Ph1 (a suppressor of homologous chromosome pairing), that when chromosomes recognise a partner to pair with, a conformational change to the chromatin is triggered in both partners that is followed by their intimate alignment. Thus, a conformational change in the chromosomes at the onset of meiosis can be correlated directly with recognition.
DescriptionBrief Communication. 3 pages; 2 figures.
Publisher version (URL)http://dx.doi.org/10.1038/ ncb1168
Appears in Collections:(IAS) Artículos
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