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Energy-dependent accumulation of fluoroquinolones in quinolone- resistant Klebsiella pneumoniae strains

AuthorsMartínez-Martínez, Luis; García, Isabel; Ballesta, Sofía; Benedí Benito, Vicente Javier; Hernández-Allés, Santiago; Pascual, Álvaro
Issue Date1998
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemotherapy 42: 1850-1852 (1998)
AbstractThe intracellular accumulation of norfloxacin and perloxacin in Klebsiella pneumoniae was evaluated. The roles of lipopolysaccharide, capsule, and outer membrane proteins were not important for the intrabacterial accumulation of fluoroquinolones in isogenic strains with known outer membrane alterations. In fluoroquinolone-resistant clinical isolates also expressing GyrA alterations, an active efflux leading to decreased accumulation of the drugs enhanced their resistance to these agents.
Identifiersissn: 0066-4804
Appears in Collections:(IMEDEA) Artículos
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