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Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes

AuthorsHernández-Allés, Santiago; Benedí Benito, Vicente Javier; Martínez-Martínez, Luis; Pascual, Álvaro; Aguilar, Alicia; Tomás, Juan M.; Albertí, Sebastián
Issue Date1999
PublisherAmerican Society for Microbiology
CitationAntimicrobial Agents and Chemotherapy 43: 937-939 (1999)
AbstractWe have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to cefoxitin in Klebsiella pneumoniae. This mechanism also operates in vivo: of 13 porin-deficient cefoxitin-resistant clinical isolates of K. pneumoniae, 4 presented ISs in their ompK36 gene.
Identifiersissn: 0066-4804
Appears in Collections:(IMEDEA) Artículos
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