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dc.contributor.authorLavado Autric, Rosalía-
dc.contributor.authorAusó Monreal, Eva-
dc.contributor.authorGarcía Velasco, José Víctor-
dc.contributor.authorArufe, María del Carmen-
dc.contributor.authorEscobar del Rey, Francisco-
dc.contributor.authorBerbel, Pere-
dc.contributor.authorMorreale de Escobar, Gabriella-
dc.identifier.citationJ Clin Invest. 2003 April 1; 111(7): 1073–1082en_US
dc.description.abstractEpidemiological studies from both iodine-sufficient and -deficient human populations strongly suggest that early maternal hypothyroxinemia (i.e., low circulating free thyroxine before onset of fetal thyroid function at midgestation) increases the risk of neurodevelopmental deficits of the fetus, whether or not the mother is clinically hypothyroid. Rat dams on a low iodine intake are hypothyroxinemic without being clinically hypothyroid because, as occurs in pregnant women, their circulating 3,5,3′-triiodothyronine level is usually normal. We studied cell migration and cytoarchitecture in the somatosensory cortex and hippocampus of the 40-day-old progeny of the iodine-deficient dams and found a significant proportion of cells at locations that were aberrant or inappropriate with respect to their birth date. Most of these cells were neurons, as assessed by single- and double-label immunostaining. The cytoarchitecture of the somatosensory cortex and hippocampus was also affected, layering was blurred, and, in the cortex, normal barrels were not formed. We believe that this is the first direct evidence of an alteration in fetal brain histogenesis and cytoarchitecture that could only be related to early maternal hypothyroxinemia. This condition may be 150–200 times more common than congenital hypothyroidism and ought to be prevented both by mass screening of free thyroxine in early pregnancy and by early iodine supplementation to avoid iodine deficiency, however mild.en_US
dc.description.sponsorshipThis work was financed by Spanish grants CICYT SAF2000-0152-C02-01 (to P. Berbel) and CAM 08.5/0059.1/2000 (to G. Morreale de Escobar).en_US
dc.format.extent3742653 bytes-
dc.publisherAmerican Society for Clinical Investigationen_US
dc.titleEarly maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progenyen_US
dc.description.peerreviewedPeer revieweden_US
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