English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/53446
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Effects of meals rich in either monounsaturated or saturated fat on lipid concentrations and on insulin secretion and action in subjects with high fasting triglyceride concentrations

AuthorsLópez, Sergio ; Bermúdez, Beatriz ; Ortega, Almudena ; Varela, Lourdes; Pacheco, Yolanda M. ; Villar Ortiz, José ; Abia, Rocío ; Muriana, Francisco J. G.
KeywordsCardiovascular diseases
Dietary fats
Fatty acids
Issue DateMar-2011
PublisherAmerican Society for Nutrition
CitationAmerican Journal of Clinical Nutrition 93(3): 494-499 (2011)
Abstract[Background]The nature of dietary fats and fasting concentrations of triglycerides affect postprandial hypertriglyceridemia and glucose homeostasis.
[Objectives] The objectives were to examine the effects of meals enriched in monounsaturated fatty acids (MUFAs) or saturated fatty acids (SFAs) on postprandial lipid, glucose, and insulin concentrations and to examine the extent of β cell function and insulin sensitivity in subjects with high fasting triglyceride concentrations.
[Design] Fourteen men with fasting hypertriglyceridemia and normal glucose tolerance were given meals (≈10 kcal/kg body weight) containing MUFAs, SFAs, or no fat. Blood samples were collected at baseline and hourly over 8 h for analysis.
[Results] The high-fat meals significantly increased postprandial concentrations of triglycerides, nonesterified fatty acids, and insulin and postprandial indexes of β cell function. However, postprandial indexes of insulin sensitivity decreased significantly. These effects were significantly attenuated with MUFAs relative to SFAs.
[Conclusions]MUFAs postprandially buffered β cell hyperactivity and insulin intolerance relative to SFAs in subjects with high fasting triglyceride concentrations. These data suggest that, in contrast with SFAs, MUFA-based strategies may provide cardiovascular benefits to persons at risk by limiting lipid and insulin excursions and may contribute to optimal glycemic control after meal challenges. © 2011 American Society for Nutrition.
Identifiersdoi: 10.3945/ajcn.110.003251
issn: 0002-9165
e-issn: 1938-3207
Appears in Collections:(IBIS) Artículos
(IG) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.