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dc.contributor.authorSolá, Rosa-
dc.contributor.authorFitó, Montserrat-
dc.contributor.authorEstruch, Ramón-
dc.contributor.authorSalas-Salvadó, Jordi-
dc.contributor.authorCorella, Dolores-
dc.contributor.authorTorre, Rafael de la-
dc.contributor.authorMuñoz, Miguel Ángel-
dc.contributor.authorLópez-Sabater, Carmen-
dc.contributor.authorMartínez-González, Miguel A.-
dc.contributor.authorArós, Fernando-
dc.contributor.authorRuiz-Gutiérrez, Valentina-
dc.contributor.authorFiol, Miquel-
dc.contributor.authorCasals, Elena-
dc.contributor.authorWärnberg, Julia-
dc.contributor.authorBuil-Cosiales, Pilar-
dc.contributor.authorRos, Emilio-
dc.contributor.authorKonstantinidou, V.-
dc.contributor.authorLapetra, José-
dc.contributor.authorSerra-Majem, Lluís-
dc.contributor.authorCovas, María Isabel-
dc.identifierdoi: 10.1016/j.atherosclerosis.2011.04.026-
dc.identifierissn: 0021-9150-
dc.identifier.citationAtherosclerosis 218(1): 174-180 (2011)-
dc.description.abstractObjectives: Apolipoprotein (Apo)B, ApoA-I, and their ratio could predict coronary heart disease (CHD) risk more accurately than conventional lipid measurements. Our aim was to assess the effect of a traditional Mediterranean diet (TMD) on apolipoproteins. Methods: High-cardiovascular risk subjects (n=551, 308 women and 243 men), aged 55-80 years, were recruited into a large, multicenter, randomized, controlled, parallel-group, clinical trial (The PREDIMED Study) aimed at testing the efficacy of TMD on primary cardiovascular disease prevention. Participants assigned to a low-fat diet (control) (n=177), or TMDs (TMD. +. virgin olive oil (VOO), n=181 or TMD. +. nuts, n=193) received nutritional education and either free VOO (ad libitum) or nuts (dose: 30. g/day). A 3-month evaluation was performed. Results: Both TMDs promoted beneficial changes on classical cardiovascular risk factors. ApoA-I increased, and ApoB and ApoB/ApoA-I ratio decreased after TMD. +. VOO, the changes promoting a lower cardiometabolic risk. Changes in TMD. +. VOO versus low-fat diet were -2.9. mg/dL (95% CI, -5.6 to -0.08), 3.3. mg/dL (95% CI, 0.84 to 5.8), and -0.03. mg/dL (-0.05 to -0.01) for ApoB, ApoA-I, and ApoB/ApoA-I ratio, respectively. Conclusions: Individuals at high-cardiovascular risk who improved their diet toward a TMD pattern rich in virgin olive oil, reduced their Apo B and ApoB/ApoA-I ratio and improved ApoA-I concentrations. © 2011 Elsevier Ireland Ltd.-
dc.description.sponsorshipThis work was supported by the Fondo Europeo de Desarrollo Regional (FEDER), by the Centro Nacional de Investigaciones Cardiovasculares (CNIC-06), and by the contract Miguel Servet (CP06/00100) from Instituto de Salud Carlos III.-
dc.subjectMediterranean diet-
dc.subjectVirgin olive oil-
dc.subjectApolipoprotein B-
dc.subjectApolipoprotein A-I-
dc.subjectApolipoprotein B/A-I-
dc.subjectCardiometabolic risk-
dc.titleEffect of a traditional Mediterranean diet on apolipoproteins B, A-I, and their ratio: A randomized, controlled trial-
dc.description.versionPeer Reviewed-
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