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Olefin metathesis-iodoetherification-dehydroiodination strategy for spiroketal subunits of polyether antibiotics.

AuthorsTony, Kurissery A.; Dabideen, Darrin; Li, Jialiang; Díaz, Dolores ; Jiménez-Barbero, Jesús ; Mootoo, David R.
Issue Date16-Oct-2009
PublisherAmerican Chemical Society
CitationJournal of Organic Chemistry 74(20):7774-80(2009)
AbstractThe convergent synthesis of two pentacyclic analogues of the polyether monensin A is described. Although different with respect to the configuration of the alcohol at the 3 position of the six-membered ring of the spiroketal subunit, the configuration at the acetal center in both structures is unchanged and is consistent with the anomeric effect. The key synthetic steps are the coupling of two complex segments via an olefin metathesis, and the subsequent conversion of a dihydroxyalkene to the spiroketal through an iodoetherification−dehydroiodination sequence. The compatibility of these transformations with a variety of functional groups makes the overall strategy appropriate for highly substituted frameworks
Description2 fig.- 7 esqu.
Publisher version (URL)http://dx.doi.org/10.1021/jo9014722
Appears in Collections:(CIB) Artículos
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