English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/53254
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Mirror represses pipe expression in follicle cells to initiate dorsoventral axis formation in Drosophila

AuthorsAndreu, María José ; González-Pérez, Esther ; Ajuria, Leiore ; Samper, Núria ; González-Crespo, Sergio ; Campuzano, Sonsoles ; Jiménez, Gerardo
Issue Date2012
PublisherCompany of Biologists
CitationDevelopment 139(6): 1110-1114 (2012)
AbstractDorsoventral (DV) axis formation in Drosophila begins with selective activation of EGFR, a receptor tyrosine kinase (RTK), in dorsal-anterior (DA) ovarian follicle cells. A critical event regulated by EGFR signaling is the repression of the sulfotransferase-encoding gene pipe in dorsal follicle cells, but how this occurs remains unclear. Here we show that Mirror (Mirr), a homeodomain transcription factor induced by EGFR signaling in DA follicle cells, directly represses pipe expression by binding to a conserved element in the pipe regulatory region. In addition, we find that the HMG-box protein Capicua (Cic) supports pipe expression in ventral follicle cells by repressing Mirr in this region. Interestingly, this role of Cic resembles its function in regulating anteroposterior (AP) body patterning, where Cic supports gap gene expression in central regions of the embryo by repressing Tailless, a repressor induced by RTK signaling at the embryonic poles. Thus, related RTK-Cic repressor circuits regulate the early stages of Drosophila DV and AP body axis formation. © 2012. Published by The Company of Biologists Ltd.
URIhttp://hdl.handle.net/10261/53254
DOI10.1242/dev.076562
Identifiersdoi: 10.1242/dev.076562
issn: 0950-1991
e-issn: 1477-9129
Appears in Collections:(IBMB) Artículos
(CBM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.