English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/53250
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Fgfr3 regulates development of the caudal telencephalon

AuthorsMoldrich, Randal X.; Mezzera, Cecilia; Holmes, William M.; Goda, Sailaja; Brookfield, Sam J.; Rankin, Alastair J.; Barr, Emily; Kurniawan, Nyoman; Dewar, Deborah; Richards, Linda J.; López-Bendito, Guillermina; Iwata, Tomoko
Issue Date2011
PublisherJohn Wiley & Sons
CitationDevelopmental Dynamics 240(6): 1586-1599 (2011)
AbstractThe fibroblast growth factor receptor 3 (Fgfr3) is expressed in a rostrallow to caudalhigh gradient in the developing cerebral cortex. Therefore, we hypothesized that Fgfr3 contributes to the correct morphology and connectivity of the caudal cortex. Overall, the forebrain structures appeared normal in Fgfr3-/- mice. However, cortical and hippocampal volumes were reduced by 26.7% and 16.3%, respectively. Hypoplasia was particularly evident in the caudo-ventral region of the telencephalon where proliferation was mildly decreased at embryonic day 18.5. Dysplasia of GABAergic neurons in the amygdala and piriform cortex was seen following GAD67 immunohistochemistry. Dye-tracing studies and diffusion magnetic resonance imaging and tractography detected a subtle thalamocortical tract deficit, and significant decreases in the stria terminalis and lateral arms of the anterior commissure. These results indicate the subtle role of Fgfr3 in formation of caudal regions of the telencephalon affecting some brain projections. © 2011 Wiley-Liss, Inc.
Identifiersdoi: 10.1002/dvdy.22636
issn: 1058-8388
e-issn: 1097-0177
Appears in Collections:(IN) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.